Multicentric lymphoma — the form characterised by widespread enlargement of peripheral lymph nodes — is actually uncommon in cats, in contrast to dogs where it is the most frequent presentation of lymphoma. In cats, this form is often associated with feline leukaemia virus (FeLV) or feline immunodeficiency virus (FIV) infection. Affected cats develop enlarged lymph nodes that can be felt under the jaw, in front of the shoulders, or behind the knees. The disease may also involve internal organs including the liver and spleen. Treatment typically follows chemotherapy protocols similar to those used in canine lymphoma, and many cats achieve initial remission, though FeLV-positive cats generally have a shorter response and poorer overall prognosis than FeLV-negative cats.