Large cell (high-grade) gastrointestinal lymphoma is a more aggressive form of intestinal cancer in cats. Unlike the small cell form, which infiltrates the intestinal lining gradually, large cell lymphoma often forms discrete masses or thickened segments of bowel and progresses more rapidly. It can arise from either T-cells or B-cells and tends to cause more dramatic symptoms including significant weight loss, poor appetite, vomiting, and sometimes abdominal masses that can be felt on examination. The prognosis is significantly more guarded than for small cell disease, with median survival typically in the range of two to nine months. Multi-drug chemotherapy protocols (similar to those used in dogs) can achieve remission in some cats, and those that respond well to initial treatment have the best outlook.