T-cell lymphoma arises from T-lymphocytes, the white blood cells that normally coordinate immune responses and destroy infected cells. Like B-cell lymphoma, it typically presents with widespread lymph node enlargement, but T-cell lymphoma carries a significantly worse prognosis. T-cell disease accounts for roughly 15–30% of multicentric lymphoma cases in dogs and is more frequently associated with elevated blood calcium levels (hypercalcaemia), which can cause increased thirst, urination, and kidney problems as a secondary complication. The cancer tends to respond less completely to standard chemotherapy protocols, and remission times are typically shorter than for B-cell lymphoma. Boxers, Golden Retrievers, and Siberian Huskies appear to be at higher risk.